Sermorelin Acetate

About Sermorelin

Sermorelin (CAS: 86168-78-7) is a synthetic peptide consisting of the first 29 amino acids of the 44-amino acid human growth hormone-releasing hormone (GHRH). This N-terminal fragment retains the full biological activity of the native hormone, as the first 29 residues contain the complete receptor-binding domain. Sermorelin was among the earliest GHRH analogs studied and has an extensive research history spanning over four decades in growth hormone physiology.

Mechanism of Action

Sermorelin binds to the GHRH receptor (GHRHR) on anterior pituitary somatotroph cells, activating adenylyl cyclase through Gs-protein coupling and increasing intracellular cAMP concentrations. In research models, this signaling cascade is studied for its role in the synthesis and secretion of growth hormone (GH) in a pulsatile manner. Unlike exogenous GH, sermorelin is studied as a tool that preserves the natural feedback architecture of the hypothalamic-pituitary-somatotroph axis in model systems, including sensitivity to somatostatin-mediated inhibition.

Published Research

• Gelato, M. C., et al. (1985). Growth hormone responses to growth hormone-releasing hormone (GHRH 1-29) in normal subjects. Journal of Clinical Endocrinology & Metabolism. DOI: 10.1210/jcem-70-1-99
• Merriam, G. R., et al. (2009). Growth hormone-releasing hormone treatment in diagnostic testing and adult GH deficiency. Journal of Clinical Endocrinology & Metabolism. DOI: 10.1210/jc.2009-0048

Product Specifications

• Molecular Weight: 3357.9 Da
• CAS Number: 86168-78-7
• Sequence: GHRH(1-29)NH2
• Purity: ≥98% (supplier batch spec; 99.4% avg across independently tested lots)
• Form: Lyophilized powder
• Storage: -20°C, protected from light

Selected lots are independently tested by Janoshik Analytical (HPLC + mass spectrometry); search by batch code at certapeptides.com/verify

This product is intended for laboratory research use only. Not for human consumption. Not a drug, food, or cosmetic. CertaPeptides does not condone or encourage any off-label use.