GHRP-2 Acetate
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About GHRP-2 Acetate
GHRP-2 (Pralmorelin) is a synthetic hexapeptide GHS-R1a agonist — among the first-generation GHRPs, it is studied for the strongest GH release per unit dose in research models. That potency is the reason it became the standard positive control in GH release assays. CAS: 158861-67-7. MW 817.9 Da. Decades of published data across multiple species and administration routes. If you need a well-characterized GHSR agonist with the widest published dataset, GHRP-2 is it.
Potency vs. Selectivity
In research models, GHRP-2 produces larger GH pulses than ipamorelin, but with less receptor selectivity. At the pituitary, it activates both GHS-R1a (GH release) and ACTH pathways, associated with elevated cortisol in research models. Prolactin rises mildly at higher doses. These off-target hormonal effects are the reason ipamorelin displaced GHRP-2 in protocols where clean GH release without cortisol confounding is required.
The off-targets are not always a problem. If the research question involves GHS-R pharmacology across pituitary cell types, ACTH axis cross-talk, or full characterization of ghrelin receptor signaling, those effects are part of the data. GHRP-2 is more useful than ipamorelin for those questions precisely because it is less selective. Comparison with GHRP-6 is also worth noting: GHRP-2 gives more GH per unit dose in research models; GHRP-6 is studied for stronger appetite stimulation through hypothalamic GHS-R activation.
Specifications
| Molecular Weight | 817.9 Da |
|---|---|
| CAS | 158861-67-7 |
| Purity | ≥98% (supplier batch spec; 99.4% avg across independently tested lots) |
| Form | Lyophilized powder |
| Sizes | 5mg, 10mg |
Storage: Lyophilized: −20°C, away from light. Once reconstituted: 2–8°C, use within 4 weeks.
Quality: Every product ships to a ≥98% supplier batch specification; selected lots are independently tested by Janoshik Analytical (HPLC + mass spectrometry; 99.4% average purity across published reports), searchable by batch code at certapeptides.com/verify. EU-based QC under CERTALAB S.R.L.
Frequently Asked Questions
How does GHRP-2 compare to ipamorelin?
In research models, GHRP-2 produces more GH per unit dose but has less receptor selectivity — it is associated with raised cortisol and prolactin alongside GH. Ipamorelin is selective for somatotroph GHS-R1a with minimal cortisol or prolactin effect. For clean GH axis research, ipamorelin is preferred. For experiments studying full GHS-R pharmacology, ACTH cross-talk, or comparative secretagogue potency, GHRP-2’s broader activity profile is the relevant one.
Why is GHRP-2 used as a positive control in GH assays?
GHRP-2 (Pralmorelin) produces reliable, strong GH responses that have been extensively validated across species and administration routes. The consistent, high-amplitude GH release makes it a dependable benchmark for comparing other secretagogues or for confirming that a GH secretion model is working correctly. Its established use as a GHS-R reference agonist further characterized the expected GH response range across research models.
For research purposes only. Not for human consumption.
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