GHK-Cu

About GHK-Cu

GHK-Cu (CAS 49557-75-7) is a tripeptide-copper complex first isolated from human plasma by Dr. Loren Pickart in 1973. Endogenous plasma concentrations decline from approximately 200 ng/mL at age 20 to 80 ng/mL by age 60, a reduction that correlates with diminished tissue remodeling capacity. This naturally occurring peptide has become one of the most studied compounds in regenerative biology and gene expression research.

Mechanism of Action

GHK-Cu functions as a biological signaling molecule that binds copper(II) ions with high affinity, facilitating copper delivery to enzymatic processes essential for tissue maintenance. The peptide activates TGF-beta and VEGF signaling pathways, stimulating fibroblast proliferation, collagen I/III synthesis, and glycosaminoglycan production. Gene expression studies using the Connectivity Map database have identified GHK as a modulator of over 4,000 human genes.

Published Research

• Gene expression modulation: Connectivity Map analysis identified GHK as capable of resetting the expression of 4,048 genes toward a profile associated with healthy tissue maintenance. (DOI)
• Tissue biology and collagen synthesis: Research demonstrated that GHK-Cu promoted tissue remodeling and increased collagen synthesis, antioxidant enzyme levels, and blood vessel formation. (DOI)
• Tissue remodeling: A comprehensive review detailed how GHK-Cu promotes extracellular matrix remodeling by stimulating synthesis of collagen, decorin, elastin, and glycosaminoglycans. (DOI)

Product Specifications

• Purity: ≥98% (supplier batch spec; 99.4% avg across independently tested lots)
• Form: Lyophilized powder
• CAS: 49557-75-7
• Molecular Weight: 403.9 Da

Selected lots are independently tested by Janoshik Analytical; reports are searchable by batch code

Third-party heavy metals + purity report: Janoshik Analytical Report #136727 (GHK-Cu 50mg) — independent lead, mercury, arsenic, cadmium analysis + HPLC purity verification by a Czech laboratory.

For research purposes only. Not for human consumption.