Semax + Selank Blend 20mg
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About Semax + Selank Blend 20mg
Semax + Selank Blend combines two Russian-developed nootropic peptides with different but complementary mechanisms in a single vial (10mg each, 20mg total). Both were developed by the Institute of Molecular Genetics of the Russian Academy of Sciences and have an unusually long research history in Russia and Eastern Europe — a distinction that provides some pharmacology data, even if that literature predates modern trial standards.
Semax is a synthetic heptapeptide derived from the ACTH(4-7) sequence with a methionine-glutamate-histidine-phenylalanine extension that increases its stability and bioactivity. In research models it is studied for its role in BDNF and NGF pathways — upregulating brain-derived and nerve growth factors. Research effects include neuroprotection, acetylcholinergic and neuropeptidergic receptor binding in memory consolidation models, and attention-related parameters. Semax has been studied in models of ischemic injury, which provides some translational context, though the evidence base is not equivalent to Western Phase III trial standards.
Selank is derived from tuftsin, an endogenous immunoregulatory peptide, with a GABA-B receptor component that gives it anxiolytic-like activity in research models. It modulates GABA system activity and reduces anxiety-like behavior in rodent models without the sedation or dependence potential associated with benzodiazepines. Selank also has immunomodulatory properties and has been studied for stress-induced immune suppression in animal models.
The combination addresses both acetylcholinergic and neuropeptidergic receptor binding (Semax) and anxiety/stress modulation (Selank) — complementary rather than redundant mechanisms in the context of cognitive performance research.
Specifications
| Parameter | Value |
|---|---|
| Component 1 | Semax 10mg (ACTH(4-7) derivative) |
| Component 2 | Selank 10mg (Tuftsin analogue) |
| Total per Vial | 20mg combined |
| Purity | ≥98% (supplier batch spec; 99.4% avg across independently tested lots, each component) |
| Format | Lyophilized powder, single-use vial |
| Storage | -20°C before reconstitution; 2-8°C after |
Storage
Store at -20°C before reconstitution. Refrigerate at 2-8°C after reconstitution and use within 28 days. Both peptides are stable under proper conditions but should be protected from light and heat.
What is the mechanism of Semax as a nootropic?
Semax is derived from the ACTH(4-7) sequence — the minimal active fragment of adrenocorticotropic hormone — modified for stability. Its primary documented mechanisms in research models involve upregulation of BDNF and NGF, neurotrophins that support neuronal survival, plasticity, and function. In rodent models it enhances learning, memory consolidation, and attention-related parameters. It also has documented neuroprotective effects in ischemia models, which is an active area of preclinical research.
How does Selank differ from conventional anxiolytics?
Selank modulates GABA system activity and has anxiolytic-like effects in rodent models, but it does not appear to act through the benzodiazepine binding site on GABA-A receptors. Benzodiazepines produce sedation, cognitive impairment, tolerance, and dependence via positive allosteric modulation at GABA-A. Selank’s mechanism appears different — it has GABA-B components and immunomodulatory effects that are not part of benzodiazepine pharmacology. In research models, Selank reduces anxiety-like behavior without the sedation or motor impairment typically associated with classical anxiolytics.
Are these peptides available as nasal sprays in Russia?
Yes. Both Semax and Selank are commercially available as intranasal sprays in Russia and some Eastern European countries, where they have regulatory approval for specific indications. The intranasal route provides efficient delivery to the CNS via the olfactory pathway, which is particularly relevant for peptides that have limited blood-brain barrier penetration via systemic routes. This product contains the lyophilized peptides for reconstitution in research applications.
Semax + Selank Blend is supplied for laboratory research use only. Not approved for human use. Handle in compliance with institutional biosafety guidelines.
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