Matrixyl 10mg
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About Matrixyl 10mg
Matrixyl is the trade name for palmitoyl pentapeptide-4 (Pal-KTTKS), a lipopeptide that emerged from wound-healing research in the early 2000s. The core sequence — lysine-threonine-threonine-lysine-serine — is a fragment of the procollagen I C-propeptide, and when palmitoylated it becomes membrane-permeable enough to reach dermal fibroblasts. That structural relationship to collagen’s own signaling machinery is what drew cosmetic and dermatological researchers to it initially.
Research Context
In vitro, Pal-KTTKS upregulates collagen I, collagen III, and fibronectin synthesis in human dermal fibroblasts. The mechanism appears to involve TGF-beta-independent pathways, which is notable because most profibrotic signals run through TGF-beta and carry the risk of excess scarring. Whether this in vitro activity translates cleanly to in vivo outcomes is still being worked out — the literature has some positive small trials and some results that are harder to interpret. The fatty acid tail matters for tissue penetration: without palmitoylation, the peptide stays largely at the surface.
Research applications include studies of extracellular matrix remodeling, fibroblast proliferation in cited models kinetics, and fibroblast behavior under aged conditions. Some groups have used Matrixyl to probe the signaling gap between procollagen processing and de novo synthesis initiation. Comparison with Matrixyl 3000 (which adds palmitoyl tripeptide-1) is another active area — the two peptides seem to engage complementary receptor populations.
Specifications
| Parameter | Value |
|---|---|
| Active compound | Palmitoyl pentapeptide-4 (Pal-KTTKS) |
| Quantity | 10mg lyophilized powder |
| Purity | ≥98% (supplier batch spec; 99.4% avg across independently tested lots) |
| Molecular weight | 802.1 Da |
| Sequence | Pal-Lys-Thr-Thr-Lys-Ser |
| Form | Lyophilized powder |
| Certificate of Analysis | Available on request |
Storage
Store at -20°C, protected from light and moisture. Stable for at least 24 months under proper conditions. Reconstitute in sterile water or PBS for laboratory use. Avoid repeated freeze-thaw cycles. Intended for research use by qualified personnel.
What distinguishes Matrixyl from other collagen-stimulating research compounds?
Its structural derivation from the procollagen C-propeptide is the key differentiator. Rather than acting as a generic growth factor stimulus, Pal-KTTKS mimics a native feedback signal that fibroblasts use to gauge collagen turnover. It also operates through TGF-beta-independent pathways, which is useful for research contexts where the standard profibrotic axis would confound results.
Does the palmitoyl group affect experimental handling?
Yes. The fatty acid tail makes the compound somewhat lipophilic, so reconstitution may require a small amount of DMSO or ethanol before aqueous dilution. For cell culture experiments, carrier concentrations should be kept low (under 0.1% DMSO) to avoid cytotoxic effects that could confound fibroblast assays. Vortexing briefly after dilution usually achieves good dispersion.
Matrixyl (Pal-KTTKS) is supplied for laboratory research use only. Not approved for human administration. For research purposes only.
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