HGH 191AA
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About HGH 191AA
HGH 191AA is recombinant human growth hormone with the full 191 amino acid sequence identical to endogenous pituitary-derived GH. It is produced via recombinant DNA technology in E. coli or CHO cell expression systems, providing a research-grade supply of the same somatropin molecule characterized in the literature. Each vial contains a specified amount in IU (international units), with the standard conversion for research-grade GH being approximately 3IU per mg.
Endogenous growth hormone is a 22kDa protein with pleiotropic effects: it stimulates IGF-1 production in the liver (the primary mediator of GH’s anabolic effects on bone and muscle), regulates lipolysis in adipose tissue, influences carbohydrate metabolism, supports immune function, and has roles in sleep architecture. GH is secreted in pulses throughout the day, with the largest pulse occurring in deep sleep — a pattern that matters for research design, since sustained elevated GH (as with continuous infusion) produces different downstream effects than pulsatile delivery.
For researchers, recombinant HGH enables study of the complete GH axis pharmacology — GH receptor binding, JAK/STAT signaling, downstream IGF-1 production, and all the downstream metabolic effects — using a well-characterized and extensively studied molecule.
Research Applications
Recombinant HGH is used in research on growth hormone axis biology, body composition (lean mass, fat distribution), bone metabolism, IGF-1 signaling, metabolic regulation, aging and GH deficiency models, and as a positive control for GH secretagogue research.
Specifications
| Parameter | Value |
|---|---|
| Compound | Recombinant Human Growth Hormone (somatropin) |
| Sequence | 191 amino acids, identical to endogenous pituitary GH |
| Purity | ≥98% (supplier batch spec; 99.4% avg across independently tested lots) |
| Format | Lyophilized powder |
| Reconstitution | Bacteriostatic water |
| Storage | 2-8°C lyophilized; 2-8°C after reconstitution |
Storage
Lyophilized HGH should be stored at 2-8°C (refrigerator) rather than frozen — freezing can damage the protein structure. After reconstitution with bacteriostatic water, store at 2-8°C and use within 28 days. Do not shake — gently swirl to dissolve.
What does 191AA mean and why does it matter?
191 amino acids is the complete length of endogenous human growth hormone. Some lower-quality research preparations (sometimes called “192AA”) contain an extra methionine residue at the N-terminus due to bacterial expression systems that don’t cleave the initiator methionine correctly. This extra methionine can increase immunogenicity — stimulating antibody formation against the GH — which confounds long-term research. True 191AA GH matches the endogenous sequence exactly, reducing this problem and making it appropriate for extended studies.
How does growth hormone produce its anabolic effects?
GH’s anabolic effects on muscle and bone are largely mediated indirectly through IGF-1. GH stimulates hepatic IGF-1 production, and circulating IGF-1 then binds IGF-1 receptors in muscle and bone to drive protein synthesis, satellite cell activation, and bone matrix production. GH also has direct effects on adipose tissue lipolysis that are independent of IGF-1. This dual mechanism — direct fat metabolism effects plus indirect IGF-1-mediated anabolic effects — is why GH produces body composition changes (reduced fat, increased lean mass) in GH-deficient animal models.
Why does storage temperature matter for HGH (refrigerator not freezer)?
Growth hormone is a protein, and freeze-thaw cycles can cause aggregation and denaturation that reduce biological activity without necessarily producing visible changes. Lyophilization (freeze-drying) removes water content and provides stability, but the reconstituted solution should be kept at 2-8 degrees C rather than frozen again. The bacteriostatic water used for reconstitution helps prevent microbial contamination during the multi-week storage period. For the lyophilized cake, refrigerator storage is acceptable and preferable to freezing to maintain protein integrity.
HGH 191AA is supplied for laboratory research use only. Not approved for human use outside of licensed pharmaceutical preparation. Handle in compliance with institutional biosafety guidelines.
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