Semax

About Semax

Semax (CAS: 80714-61-0) is a synthetic heptapeptide derived from the ACTH(4-7) fragment (Met-Glu-His-Phe) with an appended Pro-Gly-Pro tripeptide sequence to enhance metabolic stability. Developed at the Institute of Molecular Genetics of the Russian Academy of Sciences, Semax retains the neurotrophic properties of the parent ACTH fragment while resisting rapid enzymatic degradation.

Mechanism of Action

Semax influences multiple neurotransmitter systems and neurotrophic pathways. It has been shown to upregulate brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) expression in experimental models. The peptide modulates dopaminergic, serotonergic, and cholinergic neurotransmission. Research also indicates effects on gene expression patterns related to neuronal survival and plasticity, involving activation of signaling cascades including the MAPK/ERK pathway.

Published Research

• Gusev, E. I., et al. (2006). Neurotrophic effects of Semax in experimental cerebral ischemia models. Neuroscience and Behavioral Physiology. DOI: 10.1007/s11055-006-0034-0
• Eremin, K. O., et al. (2008). Semax effects on cognitive processes and neurotransmitter systems. Neuroscience and Behavioral Physiology. DOI: 10.1007/s11055-008-0037-y

Product Specifications

• Molecular Weight: 813.9 Da
• CAS Number: 80714-61-0
• Sequence: Met-Glu-His-Phe-Pro-Gly-Pro (ACTH(4-7) analog)
• Purity: ≥98% (supplier batch spec; 99.4% avg across independently tested lots)
• Form: Lyophilized powder
• Storage: -20°C, protected from light

Shipped to a ≥98% supplier batch specification; selected lots are independently tested by Janoshik Analytical (HPLC + mass spectrometry; 99.4% average purity across published reports), searchable by batch

For research purposes only. Not for human consumption.