Tesamorelin + Ipamorelin Blend 18mg
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About Tesamorelin + Ipamorelin Blend 18mg
Tesamorelin + Ipamorelin Blend combines a GHRH analogue with a selective GH secretagogue, targeting two points in the growth hormone axis simultaneously. In research models, Tesamorelin provides the GHRH signal studied for pituitary GH release; Ipamorelin provides ghrelin-mimetic stimulation through GHSR-1a. Each vial contains 9mg of each peptide (18mg total). The combination is designed to produce more robust and physiological GH stimulation than either peptide alone.
Tesamorelin is a synthetic analogue of GHRH (growth hormone-releasing hormone). It is one of very few peptides in this catalog with an established characterization in the published literature, which provides well-defined pharmacology data useful for research context. In research models, Tesamorelin is studied for stimulating pulsatile GH release by binding pituitary GHRH receptors, with the natural pulsatility of GH secretion preserved rather than producing a continuous elevation.
Ipamorelin is a highly selective GHRP that activates GHSR-1a with minimal effect on cortisol and prolactin — side effects common with earlier GHRPs like GHRP-2 and GHRP-6. This selectivity makes it the preferred GHRP for combination research where clean GH stimulation without hormonal side effects is the goal. The GHRH + GHRP combination works through complementary mechanisms and is generally more effective than either alone in preclinical research.
Research Applications
Used in research on growth hormone axis pharmacology, body composition (lean mass and fat distribution) in models, lipid metabolism, sleep architecture (GH has roles in sleep biology), and aging-related hormonal decline. The combination is well-suited for studies seeking physiological GH stimulation patterns.
Specifications
| Parameter | Value |
|---|---|
| Component 1 | Tesamorelin 9mg (GHRH analogue) |
| Component 2 | Ipamorelin 9mg (selective GHRP) |
| Total per Vial | 18mg combined |
| Purity | ≥98% (supplier batch spec; 99.4% avg across independently tested lots, each component) |
| Format | Lyophilized powder, single-use vial |
| Storage | -20°C before reconstitution; 2-8°C after |
Storage
Store at -20°C before reconstitution. Refrigerate at 2-8°C after reconstitution and use within 28 days. Avoid freeze-thaw cycles after reconstitution.
Why combine GHRH and a GHRP rather than use either alone?
GHRH and GHRPs work through complementary mechanisms: GHRH directly stimulates pituitary somatotrophs via its receptor, while GHRPs act through GHSR-1a (the ghrelin receptor) which amplifies the GHRH response through a different signaling pathway. Research consistently shows that combining GHRH with a GHRP produces substantially greater GH release than either alone — the combination is synergistic rather than merely additive. This synergy is why combination protocols are used in preclinical studies seeking robust GH stimulation.
What is unique about Tesamorelin compared to other GHRH analogues?
Tesamorelin is a stabilized analogue of GHRH(1-44) modified with a trans-3-hexenoic acid group that increases half-life. It also has an unusually well-developed pharmacology dataset compared to most research peptides in its class, which typically lack extensive characterization. That well-defined pharmacology and dose-response data provide useful context for preclinical research.
Why is Ipamorelin preferred over other GHRPs in combination research?
Ipamorelin has high selectivity for GHSR-1a with minimal action on receptors that mediate cortisol and prolactin release. Earlier GHRPs like GHRP-2 and GHRP-6 produce cortisol and prolactin elevation alongside GH stimulation, which complicates research endpoints and adds confounding variables. Ipamorelin’s cleaner profile makes it the preferred choice when the research goal is GH stimulation specifically, without concurrent stress hormone activation that could independently affect body composition or immune parameters in models.
Tesamorelin + Ipamorelin Blend is supplied for laboratory research use only. Not approved for human use. Handle in compliance with institutional biosafety guidelines.
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