Epitalon

About Epitalon

Epitalon (CAS 307297-39-8), also known as Epithalon, is a synthetic tetrapeptide with the sequence Ala-Glu-Asp-Gly (AEDG). It was synthesized based on the amino acid composition of epithalamin, a polypeptide extract derived from the bovine pineal gland. Over 25 years of published research have characterized its telomere-related, neuroendocrine, and antioxidant properties in both in vitro and in vivo models.

Mechanism of Action

Epitalon has been shown to reactivate the catalytic subunit of telomerase (hTERT) in telomerase-negative human somatic cells, leading to measurable telomere elongation. Research demonstrates dose-dependent telomere length extension through both telomerase upregulation and alternative lengthening of telomeres pathways. Additionally, epitalon modulates pineal gland function by upregulating melatonin biosynthesis enzymes, restoring circadian melatonin rhythms that decline with age.

Published Research

• Telomerase induction: Epitalon reactivated telomerase gene expression and enzymatic activity in human fetal fibroblast cultures, inducing telomere elongation in cells that normally lack telomerase. (DOI)
• Neuroendocrine restoration: Administration to aged rhesus monkeys restored nighttime melatonin levels, reduced basal glucose and insulin. (DOI)
• Comprehensive bioactivity: A systematic review confirmed significant telomere-related and neuroendocrine effects originating from antioxidant, neurotrophic, and antimutagenic activity. (DOI)

Product Specifications

• Purity: ≥98% (supplier batch spec; 99.4% avg across independently tested lots)
• Form: Lyophilized powder
• CAS: 307297-39-8
• Molecular Weight: 390.3 Da

Shipped to a ≥98% supplier batch specification; selected lots are independently tested by Janoshik Analytical (HPLC + mass spectrometry; 99.4% average purity across published reports), searchable by batch code at certapeptides.com/verify

For research purposes only. Not for human consumption.