Ipamorelin

About Ipamorelin

Ipamorelin (CAS: 170851-70-4) is a synthetic pentapeptide (Aib-His-D-2-Nal-D-Phe-Lys-NH2) belonging to the growth hormone secretagogue (GHS) class. It was developed as a highly selective agonist of the growth hormone secretagogue receptor (GHS-R1a, also known as the ghrelin receptor). Among the GHS peptide family, Ipamorelin is notable for its selectivity in stimulating GH release with minimal effects on adrenocorticotropic hormone (ACTH), cortisol, or prolactin secretion.

Mechanism of Action

Ipamorelin binds to the GHS-R1a receptor on pituitary somatotrophs, triggering growth hormone release through phospholipase C activation and intracellular calcium mobilization. Unlike other growth hormone secretagogues such as GHRP-6 or hexarelin, ipamorelin demonstrates a narrow selectivity profile, stimulating GH release in a dose-dependent manner without appreciably altering cortisol, ACTH, or prolactin levels. Additional research has explored its prokinetic effects on gastrointestinal motility through vagal cholinergic pathways.

Published Research

• Raun, K., et al. (1998). Ipamorelin, the first selective growth hormone secretagogue. European Journal of Endocrinology. DOI: 10.1530/eje.0.1390552
• Greenwood-Van Meerveld, B., et al. (1999). Stimulation of gastrointestinal tract motility by ipamorelin. Hormone Research in Paediatrics. DOI: 10.1159/000023340

Product Specifications

• Molecular Weight: 711.9 Da
• CAS Number: 170851-70-4
• Sequence: Aib-His-D-2-Nal-D-Phe-Lys-NH2
• Purity: ≥98% (supplier batch spec; 99.4% avg across independently tested lots)
• Form: Lyophilized powder
• Storage: -20°C, protected from light

Shipped to a ≥98% supplier batch specification; selected lots are independently tested by Janoshik Analytical (HPLC + mass spectrometry; 99.4% average purity across published reports), searchable by batch code at Zenith Jove.

This product is intended for laboratory research use only. Not for human consumption. Not a compound, food, or cosmetic. Zenith Jove does not condone or encourage any off-label use.