Selank

About Selank

Selank (CAS: 129954-34-3) is a synthetic heptapeptide analog of the naturally occurring immunomodulatory peptide tuftsin (threonyl-lysyl-prolyl-arginine). Developed by the Institute of Molecular Genetics of the Russian Academy of Sciences, Selank incorporates a stabilizing Pro-Gly-Pro sequence attached to tuftsin, enhancing its metabolic stability and biological activity in experimental settings.

Mechanism of Action

Selank modulates the expression and metabolism of endogenous enkephalins and their associated enzymes. Research indicates it influences the balance between enkephalin-degrading carboxypeptidase activity and enkephalin-synthesizing enzyme activity. This peptide has been shown to affect GABAergic neurotransmission and monoamine systems, including serotonin and dopamine pathways. Its tuftsin backbone also provides immunomodulatory properties through interaction with phagocytic cells and cytokine regulation.

Published Research

• Seredenin, S. B., et al. (2008). Anxiolytic effect of Selank in experimental models. Bulletin of Experimental Biology and Medicine. DOI: 10.1007/s10517-008-0156-y
• Zozulya, A. A., et al. (2008). The inhibitory effect of Selank on enkephalin-degrading enzymes as a possible mechanism of its anxiolytic activity. Biochemistry (Moscow). DOI: 10.1134/S0006297908020119

Product Specifications

• Molecular Weight: 751.9 Da
• CAS Number: 129954-34-3
• Sequence: Thr-Lys-Pro-Arg-Pro-Gly-Pro (Tuftsin analog)
• Purity: ≥98% (supplier batch spec; 99.4% avg across independently tested lots)
• Form: Lyophilized powder
• Storage: -20°C, protected from light

Shipped to a ≥98% supplier batch specification; selected lots are independently tested by Janoshik Analytical (HPLC + mass spectrometry; 99.4% average purity across published reports), searchable by batch code

This product is intended for laboratory research use only. Not for human consumption. Not a drug, food, or cosmetic. CertaPeptides does not condone or encourage any off-label use.